The Laboratory of Voiding Dysfunction
Our mission is to discover the basic cellular mechanisms underlying diseases of the lower urinary tract.
Treating symptoms is necessary but not sufficient for our patients. Until we understand the normal cellular functions of the bladder, we have little hope of understanding how diseases arise
Our investigators are performing basic research on the following: overactive bladder, urinary retention, diabetic bladder dysfunction, ketamine cystitis and brain injury (from dementia to Alzheimers to Parkinsons, to head trauma)
We use mice to perform pre-clinical research designed to:
shed light on normal bladder functions,
define the important pathways which when perturbed, cause symptoms,
identify which parts of the bladder and which cells are affected,
thereby leading to new drug targets,
and new therapeutic approaches!
Dr. Velaquez-Miranda
Works on Cloning Ion Channels from Human Bladder Tissue and Characterizing Genetic Knockouts in Mice.
Luan Le, an undergraduate from Georgia Tech participates in the Harvard Summer Research Program in Kidney Medicine. For 8 weeks in June/July 2022, he joined the lab to learn new skills and perform original research in mouse models of bladder outlet obstruction and urinary retention.
Treating symptoms is necessary but not sufficient for our patients. Until we understand the normal cellular functions of the bladder, we have little hope of understanding how diseases arise
Our investigators are performing basic research on the following: overactive bladder, urinary retention, diabetic bladder dysfunction, ketamine cystitis and brain injury (from dementia to Alzheimers to Parkinsons, to head trauma)
We use mice to perform pre-clinical research designed to:
shed light on normal bladder functions,
define the important pathways which when perturbed, cause symptoms,
identify which parts of the bladder and which cells are affected,
thereby leading to new drug targets,
and new therapeutic approaches!